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Friday, July 20, 2012

Y chromosome of Kurds in Iran Part2

Today, I want to take a deeper look into the new data of Grugni et al., 2012.

E1b1b1a1a-M34:
The frequency of M34 in Iranian Kurds is striking (13.4%). None of the other ethnic groups in Iran has such a high frequency. We have one Kurdish participant from Turkey with this haplogroup.  in our

J2a3*-Page55:
This haplogroup and its subbranches (J2a3a-M47, J2a3b*-M67, J2a3b1-M92, J2a3h-M530) seem to play a major in Kurdish ancestry. Unfortunately, 23andme is not testing some of these haplogroups, this is probably why 3 of the Kurdish DNA project participants are labeled as "J2" only.

J1-M267:
Grugni et al., 2012 observed 1.7% (1 out of 59) of this haplogroup in Iranian Kurds. The paper has some STR data that can used for comparison including 4 Iraqi Kurds.

  • Iranian Kurd: There is no perfect STR match for the Iranian Kurd (DYS19, DYS388, DYS389I, DYS389B, DYS390, DYS391, DYS392, DYS439:    13,15,12,17,25,12,11,12) of this study. The closest match in this study is an Iraqi Kurd (13,15,12,17,25,11,11,12) with one step distance. I went through my database and did not find a close match. 
  •  Iraqi Kurd#1 (13,15,12,17,25,11,11,12): this Kurd has a 1 step distance to the Iranian Kurd and no further close matches.
  • Iraqi Kurd#2  (14,13,12,16,24,10,11,12): this Kurd has two perfect matches in Eastern Turkey, most likely Kurds as well. No further close matches could be found. 
  • Iraqi Kurd#3 (14,13,13,16,23,10,11,13): One perfect match was found in Mazandaran. No further close matches could be found.
  • Iraqi Kurd#4 (14,13,14,16,23,10,11,11): No further close matches could be found.
  • We have one Kurdish Feyli participant with the J1-M267 haplogroup, however, we don't have his STR data to determine his haplotype.  
 Second look at the data (assuming correct calculations and translations): It seems like the DYS389I value does not have to be increased by 3. At least the results make much more sense when DYS389I is not increased:
  • Iranian Kurd: There is no perfect STR match for the Iranian Kurd (DYS19, DYS388, DYS389I, DYS389B, DYS390, DYS391, DYS392, DYS439:    13,15,12,17,25,12,11,12) of this study. The closest match in this study is an Iraqi Kurd (13,15,12,17,25,11,11,12) with one step distance. I went through my database and found a perfect match. It is another Kurd (Kurdish individual K9 from Tofanelli et al., 2009). 
  •  Iraqi Kurd#1 (13,15,12,17,25,11,11,12): this Kurd has a 1 step distance to the Iranian Kurd and the other Kurd described above (Kurdish individual K9 from Tofanelli et al., 2009).
  • Iraqi Kurd#2  (14,13,12,16,24,10,11,12): this Kurd has two perfect matches in Eastern Turkey, most likely Kurds as well. No further close matches could be found. 
  • Iraqi Kurd#3 ( 14,13,13,16,23,10,11,13): this haplotype seems to be more in the center of cluster. One perfect match was found in Mazandaran. I was also able to find several other perfect matches:  3 Tabasarans (D131, D148, D150: Tofanelli et al., 2009), one Central Italian (PICE15: Tofanelli et al., 2009),  and one South Lebanese Shiite Muslim (Zalloua et al., 2008). Iraqi Kurd#3 has one step distances to one Beirut Sunni Muslim (Zalloua et al., 2008), 7 Tabarasans (D133, D134, D135, D138, D142, D144, D152: Tofanelli et al., 2009), 4 Avars (D112, D098, D108, D109: Tofanelli et al., 2009), one individual from Region 7 in Turkey (Central Anatolia; Cinnioglu et al., 2004), one from Region 3 in Turkey (Northeast Anatolia), one Kubachi (D050: Tofanelli et al., 2009), one Lak (D078: Tofanelli et al., 2009).
  • Iraqi Kurd#4 (14,13,14,16,23,10,11,11): this Kurd has several perfect matches, one Lak (D062: Tofanelli et al., 2009), one Kubachi (D044: Tofanelli et al., 2009), one from Northern Portugal (Port22: Tofanelli et al., 2009), and one South Lebanese Shiite Muslim (Zalloua et al., 2008). Iraqi Kurd#4 has one step distances to 6 Laks (D063, D065, D061, D070, D081, D091: Tofanelli et al., 2009), 5 Avars (D099, D100, D102, D103, D104: Tofanelli et al., 2009), 2 Tats (D028, D039: Tofanelli et al., 2009), 2 Tajik (Haber et al., 2012), one North Lebanese Sunni Muslim (Zalloua et al., 2008), one from Southern Portugal (Port15: Tofanelli et al., 2009), one Kubachi (D045: Tofanelli et al., 2009), one Tabasaran (D126: Tofanelli et al., 2009), two individuals from Region 3 in Turkey (Northeast Anatolia), and one individual from Region 4 in Turkey (Eastern Anatolia; Cinnioglu et al., 2004).
  • We have one Kurdish Feyli participant with the J1-M267 haplogroup, however, we don't have his STR data to determine his haplotype.  
 It is striking that the same J1-M267 haplotypes are found in Kurds, Tabasarans, Avars, and Laks. This is very similar to the previous findings with 'Dogukoy' Anatolian Kurds and their Y-chromosome J2a3b*-M67 haplotypes that are very similar and/or identical to the ones found in Northeast Caucasian language speakers.


J2a3b*-M67:
  • Kurd#1 (DYS19, DYS389I, DYS389B, DYS390, DYS391, DYS392, DYS393:     14,13,19,22,10,11,12): this Kurd has two perfect matches from Albania and one from Saudi-Arabia (C_061: Abu-Amero et al., 2009). Kurd#1 has one step distances to one Tadjik from  (Haber et al., 2012), 2 individuals from Central Italy, one from Central Portugal, one from South Portugal (all from Tofanelli et al., 2009), 2 Saudi Arabians (Abu-Amero et al., 2009), one individual from Dubai (Alshamali et al., 2009), and one Lenkoran [North Talysh] (Roewer et al., 2009).
  • Kurd#2 (15,13,20,23,10,11,12): this Kurd has three perfect matches, one from Caucasus, one from Crete, one from Cyprus. Kurd#2 has one step distance to one Iraqi Kurd (#56 from Sternersen et al.)
  •  Kurd#3 (15,14,22,23,10,11,12): this Kurd does not have perfect matches. Kurd#3 has a one step distance to an Iraqi Kurd (#56 from Sternersen et al.)
J2a-M92:
  • Kurd (DYS19, DYS389I, DYS389B, DYS390, DYS391, DYS392, DYS393   14, 13, 20, 22, 10, 11, 12): this Kurd has several perfect matches, two individuals from Crete, two from Greece, one from Iran/Isfahan, and two from Turkey. 
Q1a2-M25: 
The presence of Q1a2-M25 in Turkmen reminds me of the Gokcumen paper of Central Anatolian villages. Gokcumen et al observed 13.3% haplogroup Q in the village 'Gocmenkoy' (Residents of 'Gocmenkoy' identify themselves with the Afsar clan of the Oguz tribe), whereas haplogroup Q was rare or not observed in the other Central Anatolian villages. 

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